In utero and early-life conditions and adult health and disease.

Fabry dissase from the dentist view

                 Fabry disease is a rare, inherited disease with lack of the enzyme alpha-galactosidase A (α-Gal)  in the cells of the body that participates in the breakdown of fat. The disease begins in early childhood, progresses slowly throughout life and results in severe damage of the kidneys, heart and central nervous system. The disease is life-threatening and if left untreated, death ...

In Utero and Early-Life Conditions and Adult Health and Disease

The Impact of Plasmodium Berghei Exposure In-utero on Neurobehavioral Profile in Mice

Introduction: The World Health Organization estimates that about 25 million pregnant mothers are currently at risk for malaria, and that malaria accounts for over 10,000 maternal and 200,000 neonatal deaths per year. The current hypothesis of early life programming supports the premise that many developmental delay and disorders may have their origin In-utero. Therefore, the current study aimed...

Oral Health-Related Quality of Life: A Cross-Sectional Survey among Adult Patients in Mashhad, Iran

Introduction: Quality of life is defined as the sense of well-being and satisfaction with daily performances influenced by dental and oral conditions. Oral diseases are very common and have impacts on different aspects of individual's life and can change their performances. In other word, they can change the quality of life. The real impact of health and disease on daily performances is conside...

Epigenetic effects of in utero bisphenol A administration: Diabetogenic and atherogenic changes in mice offspring

Objective(s): Bisphenol A (BPA) that is a monomer of plastic products may possibly interfere with epigenetics and be involved in onset and progression of several diseases. This study was aimed to detect the epigenetic effects of in utero BPA exposure in mice offspring.Materials and Methods: All experiments were performed according to the...

Early childhood poverty, immune-mediated disease processes, and adult productivity.

This study seeks to understand whether poverty very early in life is associated with early-onset adult conditions related to immune-mediated chronic diseases. It also tests the role that these immune-mediated chronic diseases may play in accounting for the associations between early poverty and adult productivity. Data (n = 1,070) come from the US Panel Study of Income Dynamics and include econ...